Sanjay Kharche, Ph.D.
Computational Medicine Laboratory.
Home of PM3 (Precision Medicine Using Mathematical Modeling) HPC platforms.
Kidney disease affects more than 10% of the population in Canada, and treatments are cost and resource intensive. Members of the Kidney Clinical Research Unit (KCRU), within which this lab is based, are aggressively pursuing clinical research to identify effective therapies that can be implemented at various stages of the disease. Clinical research is necessary, but must be thoroughly justified. An integrative approach will help to uncover mechanisms of disease, dialysis treatment, and of pharmacological therapies.
I am an applied mathematician. I represent poorly understood but very important cell to organ level processes in a mathematical framework as mechanistic models. I use and analyse these models to understand the inter-related dynamics of the complex organisation of electro-mechanical, fluid flow, metabolic and other multi-physics that dictate life functions and failure thereof. In addition to mathematical physiology, I also work on computational imaging that is designed to preinform our clinical-imaging research. My work is targeted towards further improvement of healthcare research and practice, but also serves developments in maths, computer science, and software engineering due to the nature of it.
A complementary physical sciences approach will further sharpen the value of our clinical trial outcomes by:
To do so, we have the following PM3 platforms: